Anti-Methicillin Resistant Staphylococcus aureus Activity of Brevibacillus laterosporus Strain SA14



We isolated strain SA14 that produced an antibacterial agent against Staphylococcus aureus and clinical isolates of methicillin-resistant S. aureus from air samples and identified it to be Brevibacillus laterosporus using API 50 CHB strips. It showed a broad range of antibacterial activity against bacteria in contaminated drinking water such as Escherichia coli and Pseudomonas and even the opportunistic microorganism Candida albicans, when investigated by the cross streak method. It excreted antimicrobial peptides into culture broth on the first day of cultivation. The peptide molecular weight determined by SDS-PAGE was 116 kDa. Characteristic measurements indicate that the peptides had a relatively gram-positive bacteria inhibitory spectrum, especially, S. aureus and MRSA, when investigated by agar well diffusion. The anti-MRSA activity was not affected by a wide pH, chemical compounds and temperature range.


Brevibacillus laterosporus, antibacterial activity, methicillin resistant Staphylococcus aureus

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