Prevalence and Patient Factors Associated with Non-steroidal Anti-inflammatory and Tricyclic Antidepressants Use among Elderly Inpatients at a District Hospital in the South of Thailand

Weerasak KHAMPHEERAPHAPKHUL, Wiyadee MATCHAROEN, Apinya KERDTALAY, Ammar DARAMA, Tanavij PANNOI

Abstract


The Thai elderly population has rapidly increased; a number of diseases have been reported, which are mainly associated with overuse of medications. Evidently, Non-steroidal Anti-inflammatory drugs (NSAIDs) and Tricyclic Antidepressants (TCAs) have been commonly given to elderly patients, which might have caused adverse drug reactions (ADRs). It is essential to use screening tools in early detection of high-risk medications (HRM) which should be weighed by their benefits and risks. This study aims to identify the prevalence and patient factors associated with HRM. The HRM screening tool, developed by a Thai working group of drug system research, was applied in this cross-sectional study. 65-year-old and older inpatients that had at least one admission at the study hospital during the fiscal year 2013 were systematically sampled. Descriptive statistics were used for conducting prevalence. Logistic regression was used to analyze the association between patient factors and HRM with type I error = 0.05. Regarding exclusion criteria, the sample of the study group used 393 elderly inpatients. 30 out of 393 inpatients (7.6 %) received HRM. The prevalence of those receiving NSAIDs, TCAs, and both, were 3.8, 3.6, and 0.3 %, respectively. Patients who had a length of hospitalization of more than 6 days were likely to be at risk of HRM compared with those of 1 to 3 days. (OR = 3.704, 95 %CI = 1.242 - 11.041, p = 0.019). In conclusion, patients who had longer hospitalizations had a higher chance of being given HRM (NSAIDs and TCAs), so that the more medications were prescribed, the higher prevalence of HRM was observed.


Keywords


High-risk medication, elderly inpatients, prevalence, Patient factors, screening tool

Full Text:

PDF

References


National Statistical Office. Report on the 2007 Survey of The Older Persons in Thailand. Bangkok, Thailand, 2011, p. 47-9.

Division of Hunan Capital Plan. Thai Statistical Elderly Persons. Bangkok, Thailand. Available from: http://www.cps.chula.ac.th/pop_info/thai/nop7/nop6/N6-WHOLE.HTM, accessed July 2014.

P Wapattanawong and P Prasatkul. Thai Population in the Future 2011. Available from: http://www.ipsr.mahidol.ac.th/IPSR/AnnualConference/ConferenceII/Article/Article02.htm, accessed July 2014.

Institute of Geriatric Medicine, Ministry of Public Health. The 2001 Survey of Quality of Life of the Older Persons. Bangkok, Thailand, 2011.

W Winit-Watjana, P Sakulrat and J Kespichayawattana. Criteria for high-risk medication use in Thai older patients. Arch. Gerontol. Geriatr. 2008; 47, 35-51.

C Ploylueamsang, K Tiankanithikul, J Choppradit, S Soonthorn and V Suwankesawong. QUM2.2: Development of Medicine List for Screening and Reducing Medication-Related Problems in Thai Elderly Quality Use of Medicine Project. Health System Research Institution, Nonthaburi, Thailand, 2012.

F Napolitano, MT Izzo, GD Giuseppe and IF Angelillo. Frequency of inappropriate medication prescription in hospitalized elderly patients in Italy. Plos One 2013; 8, 1-7.

D Opondo, S Eslami, S Visscher, D Rooijse, R Verheij, JC Korevaar and A Abu-Hanna. Inappropriateness of medication prescriptions to elderly patients in the primary care setting: A Systematic Review. Plos One 2012; 7, 1-9.

G Parthasarathi, M Ramesh, S Guido, A Harugeri and J Joseph. Potentially inappropriate medication use in elderly patients: A study of prevalence and predictors in two teaching hospitals. J. Postgrad. Med. 2010; 56, 186.

HN Vishwas, A Harugeri, G Parthasarathi and M Ramesh. Potentially inappropriate medication use in Indian elderly: Comparison of Beers' criteria and Screening Tool of Older Persons' potentially inappropriate Prescriptions. Geriatr. Gerontol. Int. 2012; 12, 506-14.

T Pannoi, RS Chapman and A Panza. Prevalence of potentially inappropriate medication (PIM) and factors associated with PIM in elderly outpatient prescriptions at a district hospital in the southern region of Thailand. J. Health Res. 2014: 28, 101-8.


Refbacks

  • There are currently no refbacks.




http://wjst.wu.ac.th/public/site/images/admin/image012_400

Online ISSN: 2228-835X

http://wjst.wu.ac.th

Last updated: 2 August 2017