Factors influencing early neurological recovery in patients with acute ischemic stroke

Orapen SUKHAVULLI, Siriorn Sindhu, Wanpen Pinyopassakul, Chukiat Viwatwongkasem

Abstract


The purposes of this  cross-sectional descriptive study were to describe the early neurological recovery in patients with acute ischemic stroke and to identify the statistical predictors of early neurological recovery at 24 hours and 3 days after admission. A purposive random sampling was employed to recruit 220 AIS patients from 8 hospitals in the southern region of Thailand starting from January to May 2016, and analyzed using multivariate logistic regression analysis.

The result revealed that moderate and severe stroke severity decreased the neurological recovery at 24 hours (OR =.095, p <.001 and OR =.126, p <.01, respectively), compared with mild stroke severity. In addition, onset time to rt-PA within 3 hours and 3.0-4.5 hours increased the neurological recovery at 24 hours (OR=22.22, P <.001 and OR =17.28, P <.01, respectively), compared with those who did not receive rt-PA treatment.  Lastly, age >80 years decreased neurological recovery at 24 hours after admission (OR=.361, P <.05).

For the neurological recovery at 3 days, showed that moderate and severe stroke severity decreased the neurological recovery (OR=.10, p <.001and OR =.09, p <.001, respectively), compared with mild stroke severity. The stroke patients who had onset time to rt-PA within 3 hours and  within 3.0-4.5 hours increased the neurological recovery at 3 days (OR=16.95, P <.05 and OR =14.43, P<.01, respectively) compared with those who did not receive rt-PA treatment.

The study showed that stroke severity and onset time to rt-PA influence early neurological recovery in AIS patients.The result revealed that moderate and severe stroke severity decreased the neurological recovery at 24 hours (OR =.095, p <.001 and OR =.126, p <.01, respectively), compared with mild stroke severity. In addition, onset time to rt-PA within 3 hours and 3.0-4.5 hours increased the neurological recovery at 24 hours (OR=22.22, P <.001 and OR =17.28, P <.01, respectively), compared with those who did not receive rt-PA treatment.  Lastly, age >80 years decreased neurological recovery at 24 hours after admission (OR=.361, P <.05).

For the neurological recovery at 3 days, showed that moderate and severe stroke severity decreased the neurological recovery (OR=.10, p <.001and OR =.09, p <.001, respectively), compared with mild stroke severity. The stroke patients who had onset time to rt-PA within 3 hours and  within 3.0-4.5 hours increased the neurological recovery at 3 days (OR=16.95, P <.05 and OR =14.43, P<.01, respectively) compared with those who did not receive rt-PA treatment.

The study showed that stroke severity and onset time to rt-PA influence early neurological recovery in AIS patients.

Keywords


Early neurological recovery; Acute ischemic stroke; Stroke severity; Onset-time-to rt-PA

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