Bioactive Constituents from the Twigs of Sonneratia alba
Keywords:Sonneratia alba, Sonneraceae, Triterpenoids, Quinone, Antimalarial, Antimycobacterial
AbstractThree pentacyclic triterpenoids: lupeol , oleanolic acid , and betulinic acid  were isolated from the twigs of Sonneratia alba together with 2,6-dimethoxy-p-benzoquinone , a mixture of stigmasterol  and b-sitosterol . Their structures were elucidated by analyses of their 1D and 2D NMR, and their physical and spectral data were compared with those reported in the literature. Amongst these isolates, compounds [2,3] exhibit antimycobacterial activity with MIC values of 25 and 50 mg/ml respectively. In addition, compound  exhibited antimalarial activity against P. falciparum with an IC50 value of 3.08 mg/ml.
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