Bioactive Constituents from the Twigs of Sonneratia alba

Kanchuree CHAIYADEJ; Hathaichanok WONGTHAP; Surasi VADHANAVIKIT; Kan CHANTRAPROMMA

Authors

Kanchuree CHAIYADEJ Center for Scientific and Technological Equipment, Walailak University, Thasala, Nakhon Si Thammarat 80161
Hathaichanok WONGTHAP School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80161
Surasi VADHANAVIKIT School of Allied Health Sciences and Public Health, Walailak University, Thasala, Nakhon Si Thammarat 80161
Kan CHANTRAPROMMA School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80161

Keywords:

Sonneratia alba, Sonneraceae, Triterpenoids, Quinone, Antimalarial, Antimycobacterial

Abstract

Three pentacyclic triterpenoids: lupeol [1], oleanolic acid [2], and betulinic acid [3] were isolated from the twigs of Sonneratia alba together with 2,6-dimethoxy-p-benzoquinone [4], a mixture of stigmasterol [5] and b-sitosterol [6]. Their structures were elucidated by analyses of their 1D and 2D NMR, and their physical and spectral data were compared with those reported in the literature. Amongst these isolates, compounds [2,3] exhibit antimycobacterial activity with MIC values of 25 and 50 mg/ml respectively. In addition, compound [4] exhibited antimalarial activity against P. falciparum with an IC50 value of 3.08 mg/ml.

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