Bioactive Constituents from the Twigs of Sonneratia alba

Kanchuree CHAIYADEJ, Hathaichanok WONGTHAP, Surasi VADHANAVIKIT, Kan CHANTRAPROMMA

Abstract


Three pentacyclic triterpenoids: lupeol [1], oleanolic acid [2], and betulinic acid [3] were isolated from the twigs of Sonneratia alba together with 2,6-dimethoxy-p-benzoquinone [4], a mixture of stigmasterol [5] and b-sitosterol [6]. Their structures were elucidated by analyses of their 1D and 2D NMR, and their physical and spectral data were compared with those reported in the literature. Amongst these isolates, compounds [2,3] exhibit antimycobacterial activity with MIC values of 25 and 50 mg/ml respectively. In addition, compound [4] exhibited antimalarial activity against P. falciparum with an IC50 value of 3.08 mg/ml.

Keywords


Sonneratia alba, Sonneraceae, Triterpenoids, Quinone, Antimalarial, Antimycobacterial

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References


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