Anti-Hyperlipidemia and Anti-obesity Properties of Garcinia atroviridis and Camellia sinensis Extracts in High-Fat Diet Mice


  • Anawat KONGCHIAN Division of Biomedical Sciences, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Narissara KEAWBOONLERT Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Thanchanok BOONRAK Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Sarai LOOKYEE Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Krittiyaporn BUASRI Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Nassaree SURONGKUL Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand
  • Jitbanjong TANGPONG Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80161, Thailand



Anti-hyperlipidemia, Anti-glycemic, Atherosclerosis, Camellia sinensis, Garcinia atroviridis, High-fat diet mice, Cardiovascular disease


Hyperlipidemia and obesity are risk factors that contribute to cardiovascular diseases, diabetes, and hypertension among the world’s population. The present study aimed to investigate the effects of green tea (Camellia sinesis) and Garcinia (Garcinia atroviridis) extracts in high-fat diet mice. The mice were fed with a high-fat diet and orally administrated extracts once daily. The extracts displayed a significant decrease in body weight, triglyceride, low-density lipoprotein (LDL) cholesterol, total cholesterol, atherosclerosis index (AI), and glucose levels in blood. High-density lipoprotein (HDL) cholesterol significantly increased. Treatment with the extracts reduced the lipid peroxidation marker, malondialdehyde (MDA), and indicated the pathohistology of lower fat cells deposited in liver tissues. In in vitro studies, the extracts have been identified to be capable of inhibiting the activity of amylase and glucoside enzymes and scavenging free radicals. Moreover, both green tea and Garcinia extracts showed non-toxicity as presented by the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN). In conclusion, the pathogenic factors involved in atherosclerosis were reduced by green tea and Garcinia extracts, and both extracts could be useful for better prevention and treatment of atherosclerosis and cardiovascular diseases.


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How to Cite

KONGCHIAN, A. ., KEAWBOONLERT, N. ., BOONRAK, T. ., LOOKYEE, S. ., BUASRI, K. ., SURONGKUL, N. ., & TANGPONG, J. . (2020). Anti-Hyperlipidemia and Anti-obesity Properties of Garcinia atroviridis and Camellia sinensis Extracts in High-Fat Diet Mice. Walailak Journal of Science and Technology (WJST), 17(10), 1126–1138.