TY - JOUR AU - MUNGMAI, Lapatrada AU - PREEDALIKIT, Weeraya AU - RUNGSANG, Tammanoon AU - SAINAKHAM, Mathukorn PY - 2021/03/01 Y2 - 2024/03/19 TI - Bioactivity Determination and Development of Oil in Water Emulsion Containing Cassia fistula Bark Extract JF - Walailak Journal of Science and Technology (WJST) JA - Walailak J Sci & Tech VL - 18 IS - 5 SE - Research Article DO - 10.48048/wjst.2021.8943 UR - https://wjst.wu.ac.th/index.php/wjst/article/view/8943 SP - Article 8943 (10 pages) AB - <p>The determination of active contents, free radical scavenging, and tyrosinase inhibition activity of <em>Cassia fistula</em> extracts for skincare development is presented in this study. <em>C. fistula</em> was extracted by 95 % ethanol. The extracts were then determined for total phenolic content, phytochemical constituents, free radical scavenging, and tyrosinase inhibition activity. The formulation containing the selected <em>C. fistula</em> extract was prepared and examined for this formulation's bioactivities and stability. <em>C. fistula</em> extract from the bark provided the highest total phenolic content and free radical scavenging activity of 22.35±1.38 mgGAE/g and the IC<sub>50</sub> value of 7.90±0.10 μg/mL, respectively. <em>C. fistula</em> extract from the bark was observed having tyrosinase inhibition activity at the IC<sub>50</sub> value of 1.71×10<sup>3</sup>±0.01 μg/mL and selected to be an active ingredient in oil in water emulsion. At 4±2 °C storage, the formulation containing <em>C. fistula</em> extract from bark showed the highest stability without changing the color, odor, homogeneity, while pH and viscosity were slightly changed. The formulation’s bioactivities containing <em>C. fistula</em> extract from bark were slightly decreased in all temperatures at the end of the stability test. In this study, <em>C. fistula</em> extract from the bark can potentially inhibit tyrosinase in a free radical scavenging activity. Therefore, it may be an appropriate choice for skincare products that aim to provide whitening effects.</p> ER -