@article{OUNJAIJEAN_SOMSAK_2020, title={Preliminary Study on Hepatoprotective Activity of Aqueous Crude Extract of Allium ascalonicum against Ethanol-induced Liver Injury in Mice}, volume={17}, url={https://wjst.wu.ac.th/index.php/wjst/article/view/10708}, DOI={10.48048/wjst.2020.10708}, abstractNote={<p>Ethanol-induced liver injury is an aggravated liver disease with a diverse spectrum from steatosis to hepatitis, fibrosis, and cirrhosis. Epidemiological studies reveal that ethanol-induced liver injury has become one of the most intense threats to global health. Therefore, this study investigated the hepatoprotective property of <em>Allium ascalonicum</em> extract against ethanol-induced liver injury in mice. Aqueous crude extract of <em>A. ascalonicum</em> bulbs was prepared, and acute toxicity was, then, carried out in mice. The results indicated that <em>A. ascalonicum</em> extract at the dose up to 2,000 mg/kg/day did not cause mortality and liver injury as indicated by non-significant differences in AST, ALT, GGT, and ALP levels, compared to healthy control within the monitoring period. For <em>in vivo</em> efficacy test, the experimental mice were orally administered with 50 % (v/v) ethanol for 14 consecutive days, then further treated with the extract (50, 100, and 200 mg/kg) once a day for another 7 consecutive days. Significant, dose-dependent decrease of AST, ALT, GGT, and ALP levels was observed in ethanol-induced liver injury mice treated with <em>A. ascalonicum</em> extract. The present study clearly demonstrated that the aqueous crude extract of <em>A. ascalonicum</em> bulbs exert a hepatoprotective effect against ethanol-induced liver injury in the mice model. <em>A. ascalonicum</em> extract might be a promising remedy to treat alcoholic liver disease.</p>}, number={10}, journal={Walailak Journal of Science and Technology (WJST)}, author={OUNJAIJEAN, Sakaewan and SOMSAK, Voravuth}, year={2020}, month={Oct.}, pages={1088–1094} }