Structural, Thermal and Surface Properties of a Formulated Sunscreen: Zn/Al-nitrate Layered Double Hydroxide Intercalated with 4-aminobenzoic Acid
Keywords:Zn/Al layered double hydroxide, 4-aminobenzoic acid, Sunscreen formulation, Intercalation, Skin
Intercalation of 4-amino benzoic acid (4-AB) into Zn/Al-nitrate layered double hydroxide (ZAL2) to form Zn/Al-4AB (ZALAB) compound was successfully synthesized from nitrate salt by using direct co-precipitation method. ZALAB compound was confirmed by Powder X-ray diffraction (PXRD) pattern with a basal spacing of 15.3 Å. The presence of COO- and C6H5NH2 functional groups of 4-AB at 1,517 and 1,178 cm–1 in Fourier transform infrared (FTIR) spectrum reinforced 4-AB intercalated into the resulting compound. Based on the thermal analysis, 4-AB in ZALAB compound was more stable compared to pure 4-AB. Breuneur, Emmet and Teller/Barret-Joyner-Halenda (BET/BJH) analyses demonstrated that ZALAB compound is a mesopores-type IV compound with 4.25 m2/g surface area. This material is an irregular shape with different sizes of particles. ZALAB is a potential sunscreen formulation that minimizes the harmful effect on the skin, improving pharmaceutical technology in the skincare treatment.
- 4-amino benzoic acid (4-AB) is a sunscreen composed of carboxylic and aromatic groups that potentially filter UV-B radiation
- Layered double hydroxide (LDH) is known as an ionic clay that is based on the brucite (Mg (OH)2) -like cations layers containing intercalated charge-balancing anions and water
- Intercalation of 4-amino benzoic acid (4-AB) into Zn/Al-nitrate layered double hydroxide (ZAL2) to form Zn/Al-4AB (ZALAB) was synthesized using direct co-precipitation method
- ZALAB material has a higher thermal stability compared to 4-AB in pure form
ACT Cursino, JEFDC Gardolinski and F Wypych. Intercalation of anionic organic ultraviolet ray absorbers into layered zinc hydroxide nitrate. J. Colloid Interf. Sci. 2010; 347, 49-55.
RL Rietschel, JF Fowler and AA Fisher. Fisher’s contact dermatitis. Bc Decker, New York, 2008, p. 88-110.
BS Mackie, LE Mackie and Australas. Reactions with Aminobenzoic acids via diazonium salts open new routes to bio-derived aromatics. J. Dermatol. 1999; 40, 51-3.
CD Hoyo. Layered double hydroxides and human health: An overview. Appl. Clay Sci. 2007; 36, 103-21.
L Perioli, V Ambrogi, B Bertini, M Ricci, M Nocchetti, L Latterini and C Rossi. Anionic clays for sunscreen agent safe use: Photoprotection, photostability and prevention of their skin penetration. Eur. J. Pharm. Biopharm. 2006; 62, 185-93.
Y Feng, D Li, Y Wang, DG Evans and X Duan. Synthesis and characterization of a UV absorbent-intercalated Zn-Al layered double hydroxide. Poly Degrad. Stabi. 2006; 91, 789-94.
IT Roto and Mustofa. Zn-Al layered double hydroxide as host material for sunscreen compound of p-aminobenzoic acid. Indo. J. Chem. 2007; 7, 1-4.
INFA Aziz, SH Sarijo, FSM Rajidi, R Yahaya and M Musa. Synthesis and characterization of novel 4-aminobenzoate interleaved with zinc layered hydroxide for potential sunscreen application. J. Porous Mater. 2019; 26, 717-22.
Q He, S Yin and T Sato. Synthesis and photochemical properties of zinc-aluminum layered double hydroxide/organic UV ray absorbing molecule/silica nanocomposites. J. Phys. Chem. Solids 2004; 65, 395-402.
JH Choy, SY Kwak, YS Han and BW Kim. New organo-montmorillonite complexes with hydrophobic and hydrophilic functions. Mater. Lett. 1997; 33, 143-7.
L Qin, M Wang, R Zhu, S You, P Zhou and S Wang. The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids. Int. J. Nanomedicine 2013; 8, 2053-64.
SH Sarijo, MZ Hussein, AH Yahaya, Z Zainal and MA Yarmo, Synthesis of phenoxyherbicides-intercalated layered double hydroxide nanohybrids and their controlled release property. Curr. Nanosci. 2010; 6, 199-205.
S Li, Y Shen, M Xiao, D Liu, L Fa and K Wu. Intercalation of 2,4-dihydroxybenzophenone-5-sulfonate anion into Zn/Al layered double hydroxides for UV absorption properties. J. Indus. Eng. Chem. 2014; 20, 1280-4.
MZ Hussein, Z Zainal, AH Yahaya and DWV Foo. Controlled release of a plant growth regulator, alpha-naphthaleneacetate from the lamella of Zn-Al-layered double hydroxide nanocomposite. J. Control. Rel. 2002; 82, 417-27.
SMN Mohsin, MZ Hussein, SH Sarijo, S Fakurazi, P Arulselvan and TYY Hin. Synthesis of (cinnamate-zinc layered hydroxide) intercalation compound for sunscreen application. Chem. Cent. J. 2013; 7, 26.
SH Sarijo, A Ahmad, SMN Muhsin and Z Jubri. Synthesis of layered organic-inorganic nanohybrid zinc-aluminium-2-(4-chlorophenoxy)-2-methyl propionic acid with controlled release properties. J. Porous Mater. 2019; 26, 41-50.
F Barahuie, MZ Hussein, SA Gani, S Fakurazi and Z Zainal. Synthesis of protocatechuic acid-zinc/aluminium-layered double hydroxide nanocomposite as an anticancer nanodelivery system. J. Solid State Chem. 2015; 221, 21-31.
E Conterosito, L Palin, D Antonioli, D Viterbo, E Mugnaioli, U Kolb, L Perioli, M Milanesio and V Gianotti. Structural characterisation of complex layered double hydroxides and TGA-GC-MS study on Thermal Response and Carbonate Contamination in Nitrate- and Organic-Exchanged hydrotalcites. Chem. A Eur. J. 2015; 21, 14975-86.
M Ghadiri, W Chrzanowski and R Rohanizadeh. Antibiotic eluting clay mineral (Laponite) for wound healing application: An in vitro study. J. Mater. Sci. Mater. Med. 2014; 25, 2513-26.
Y Wei, Y Gao, Q Xie, G Zhang and W Fu. Isolation of chlorogenic acid from Flaveria bidentis (L.) Kuntze by CCC and synthesis of chlorogenic acid-intercalated layered double hydroxide. Chromatographia 2011; 73, 97-102.
Y Zhi, Y Li, Q Zhang and H Wang. ZnO nanoparticles immobilized on flaky layered double hydroxides as photocatalysts with enhanced adsorptivity for removal of acid red G. Langmuir 2010; 26, 15546-53.
Z Jubri, MZ Hussein, AH Yahaya and Z Zainal. The effect of substitution of zinc with aluminium in the brucite-like layers on the physicochemical properties of zinc-aluminium-layered double hydroxide-pamoate nanocomposite. J. Porous Mater. 2012; 19, 45-51.
M Mamat, E Kusrini, AH Yahaya, MZ Hussein and Z Zainal. Intercalation of anthranilate ion into zinc-aluminium-layered double hydroxide. Int. J. Technol. 2013; 4, 73-80.
How to Cite
Copyright (c) 2021 Walailak University
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.