Opinion to: Design, Synthesis, Antimicrobial, and Antioxidant Activities of Novel {4,5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl Chloride

Khamid U. KHODJANIYAZOV; Kohei TORIKAI

doi:10.48048/wjst.2019.6414

Authors

Khamid U. KHODJANIYAZOV Faculty of Chemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent 100174
Kohei TORIKAI Department of Chemistry, Faculty of Science, Kyushu University, Fukuoka 819-0395 http://orcid.org/0000-0002-9928-4300

DOI:

https://doi.org/10.48048/wjst.2019.6414

Keywords:

Opinion, acid chlorides, thioesters, 1,2,4-triazole

Abstract

To discover novel triazole-based antimicrobial agents, design and synthesis of acid chlorides possessing a 1,2,4-triazole core was reported in this journal in 2018. However, we found that the reported spectroscopic data did not show any agreement with the proposed acid chloride structure. Herein, we described our opinion, which was supported by IR data, circumstantial evidences, and mechanistic insight, that the products obtained in the topical paper would be thioesters.

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Author Biography

Kohei TORIKAI, Department of Chemistry, Faculty of Science, Kyushu University, Fukuoka 819-0395

Department of Chemistry, Faculty of Science, Assistant Professor

References

M Kumar, N Malik, P Dhiman, PK Verma and A Khatahar. Design, synthesis, antimicrobial, and antioxidant activities of novel {4,5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl chloride. Walailak J. Sci. & Tech. 2018; 15, 157-67.

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Other than these, there are some minor points: The reported 1H–NMR data do not show any multiplicities and J values, to hamper the detailed structure confirmation of the readers. Nomenclatures are occasionally incorrect (e.g. compound 2a1 is named as 2-(4-(2,6-dichlorophenyl)-5-(4-nitrophenyl)-4H-1,2,4-triazol-3-ylthio)acetyl chloride, but it should be 2-(4-(2,3-dichlorophenyl)-5-(4-nitrophenyl)-4H-1,2,4-triazol-3-ylthio)acetyl chloride).

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