Opinion to: Design, Synthesis, Antimicrobial, and Antioxidant Activities of Novel {4,5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl Chloride



To discover novel triazole-based antimicrobial agents, design and synthesis of acid chlorides possessing a 1,2,4-triazole core was reported in this journal in 2018. However, we found that the reported spectroscopic data did not show any agreement with the proposed acid chloride structure. Herein, we described our opinion, which was supported by IR data, circumstantial evidences, and mechanistic insight, that the products obtained in the topical paper would be thioesters.


Opinion, acid chlorides, thioesters, 1,2,4-triazole

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M Kumar, N Malik, P Dhiman, PK Verma and A Khatahar. Design, synthesis, antimicrobial, and antioxidant activities of novel {4,5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl chloride. Walailak J. Sci. & Tech. 2018; 15, 157-67.

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Other than these, there are some minor points: The reported 1H–NMR data do not show any multiplicities and J values, to hamper the detailed structure confirmation of the readers. Nomenclatures are occasionally incorrect (e.g. compound 2a1 is named as 2-(4-(2,6-dichlorophenyl)-5-(4-nitrophenyl)-4H-1,2,4-triazol-3-ylthio)acetyl chloride, but it should be 2-(4-(2,3-dichlorophenyl)-5-(4-nitrophenyl)-4H-1,2,4-triazol-3-ylthio)acetyl chloride).

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Last updated: 12 August 2019