Prospect of Plant-based Flavonoids to Overcome Antibacterial Resistance: A Mini-Review


  • Abdi Wira SEPTAMA Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Tangerang Selatan 15314, Indonesia
  • Nordin SIMBAK Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud 20400, Kuala Terengganu, Terengganu, Malaysia
  • Eldiza Puji RAHMI Faculty of Medicine, Universitas Pembangunan Nasional Jakarta, Jl. Rs. Fatmawati, Pondok Labu, Jakarta Selatan 12450, Indonesia



Antibiotic, Antibacterial, Bacterial resistant, Flavonoid, Natural product, Synergistic


Although antibiotic has been frequently used for the treatment of infection, it has led to the emergence of resistant problem. Plant-derived compounds are alternative source for discovering novel therapeutics. Flavonoid is widely distributed and present in plant kingdom. This compound possessed several pharmacological properties including antibacterial. This review aims to present some information about the potency of flavonoids as antibacterial compound including their mechanism of antibacterial action as well as the relationship between their activity and flavonoid structure. The synergistic effect of flavonoids when used in combination with antibiotics against resistant bacterial is also described. Published literatures were collected from data bases such as PubMed, Google Scholar, Science Direct and Scopus. Scientific papers were selected based on information of antibacterial activity of flavonoid compounds. The information may provide an insight on the potency of flavonoid compounds to overcome resistant problem.


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How to Cite

SEPTAMA, A. W. ., SIMBAK, N. ., & RAHMI, E. P. . (2019). Prospect of Plant-based Flavonoids to Overcome Antibacterial Resistance: A Mini-Review. Walailak Journal of Science and Technology (WJST), 17(5), 503–513.