Review of Anti-Hyperglycemic Effect of Tinospora crispa
Keywords:Tinospora crispa, borapet, borapetoside C, diabetes mellitus, anti-hyperglycemic effect
Tinospora crispa (Borapet or Wan kab hoi yai) is a climbing plant belonging to family Menispermaceae. In traditional medicine, an extract from the stems of T. crispa has been used for anti-hyperglycemic activity. The mechanisms of the anti-hyperglycemic actions of T. crispa are due to the stimulation of insulin secretion, enhancement of glucose utilization in peripheral tissues and reduction of hepatic gluconeogenesis. Borapetoside A and C are active ingredients for lower plasma glucose. In human studies, T. crispa extract possesses a significant anti-hyperglycemic effect in metabolic syndrome but this effect is abolished in type 2 diabetes mellitus. More clinical studies are recommended to evaluate the beneficial effect of T. crispa in human models.
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