Review of Anti-Hyperglycemic Effect of Tinospora crispa


  • Theerawut KLANGJAREONCHAI Department of Medicine, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400
  • Supanee PUTADECHAKUM Research Center, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400
  • Chulaporn ROONGPISUTHIPONG Department of Medicine, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400


Tinospora crispa, borapet, borapetoside C, diabetes mellitus, anti-hyperglycemic effect


Tinospora crispa (Borapet or Wan kab hoi yai) is a climbing plant belonging to family Menispermaceae. In traditional medicine, an extract from the stems of T. crispa has been used for anti-hyperglycemic activity. The mechanisms of the anti-hyperglycemic actions of T. crispa are due to the stimulation of insulin secretion, enhancement of glucose utilization in peripheral tissues and reduction of hepatic gluconeogenesis. Borapetoside A and C are active ingredients for lower plasma glucose. In human studies, T. crispa extract possesses a significant anti-hyperglycemic effect in metabolic syndrome but this effect is abolished in type 2 diabetes mellitus. More clinical studies are recommended to evaluate the beneficial effect of T. crispa in human models.



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How to Cite

KLANGJAREONCHAI, T., PUTADECHAKUM, S., & ROONGPISUTHIPONG, C. (2015). Review of Anti-Hyperglycemic Effect of Tinospora crispa. Walailak Journal of Science and Technology (WJST), 12(5), 403–406. Retrieved from