Epidermal Modification in Skin of Streptozotocin-induced Diabetic Rats



Delayed wound healing is one of complications in the diabetic dermopathy, and potentially causes chronic ulceration and limb amputation. To investigate the effects of diabetes on the skin, male Sprague-Dawley rats were used. After 24 weeks of a single dose of streptozotocin administration, the skin was removed as part of the histological process to produce microscopic slides and was viewed under a light microscope. It was shown that the thickness of the epidermis in long-termed diabetic rats decreased. Additionally, in the long-termed diabetic group, hypertrophic keratinocytes and pyknotic melanocytes were also observed in the stratum basale. The size of keratinocyte and its nucleus in the stratum spinosum was smaller. In addition, there was a dense-stained layer with shreds in the stratum corneum. It was concluded that long-termed diabetes causes these pathological aspects of the skin, and might further contribute to chronic wound formation. Therefore, skin problems should be managed with early diagnosis and treatment, in order to improve quality of life in diabetic patients.


Diabetic dermopathy, diabetes mellitus, epidermis

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