Development of Tamarind Seed Gum as Dry Binder in Formulation of Diclofenac Sodium Tablets
Keywords:Tamarind seed gum, dry binder, tablets, diclofenac sodium, carboxy-methylation
AbstractTamarind (Tamarindus indica Linn.) is tropical plant, which is generally found and planted in Thailand. The application of tamarind seed gum can raise the value of tamarind and minimize industrial waste. Tamarind seed gum powder offers a high viscosity solution. Therefore, researchers are interested in developing tamarind seed gum as a binder in the formulation of diclofenac sodium tablet, prepared by the dry granulation method. Physicochemical characterization results show that the carboxymethylation process can add a carboxymethyl group to the chemical structure of crude gum. The success of chemical modification was confirmed by Fourier transformed infrared (FTIR) result. A powder X-ray diffractogram expressed that the gum in, the crude and modified forms, were in amorphous form. The melting point, solubility properties, and viscosity of the polymer solution increased after the chemical structure modification. However, the disintegration time of the tablet made of the modified gum was too long. Consequently, an appropriate amount of gum powder (40 - 70 mg/tablet) was optimized. The result found that hardness of the tablet did not depend on the gum amount. Increasing the portion of the gum in the formulation retarded disintegration time and drug dissolution. The proper amount of the modified gum in the formulation was 60 mg (7.61 % w/w). The hardness of the tablet was 61 N, with 1.99 % of tablet friability. Disintegration time was less than 15 min, and drug release reached 76 % in 20 min.
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