Novel Series of Pyrimidine Derivatives as Anti-inflammatory Agents
Keywords:Pyrimidine, anti-inflammatory activity, rat paw edema
A series of compound 6-bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one (BT1M-T10M), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (BT1P-BT10P) has been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one (T1-T10). The structures of the synthesized compounds were elucidated by I.R., 1HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by a carrageenan-induced rat paw edema method. Among them, compounds BT8M, BT4P, BT5P, and BT7P exhibited significant anti-inflammatory activity. Compounds BT3M, BT9M, BT10M, BT9P, and BT10P showed highly significant anti-inflammatory activity. The remaining compounds showed less anti-inflammatory activity, comparable to that of standard drug diclofenac sodium.
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