Novel Series of Pyrimidine Derivatives as Anti-inflammatory Agents

Anshu CHAYDHARY; Anoop SINGH; Prabhakar KUMARVERMA

Authors

Anshu CHAYDHARY Nims Institute of Pharmacy, Nims University, Rajasthan
Anoop SINGH Nims Institute of Pharmacy, Nims University, Rajasthan
Prabhakar KUMARVERMA Department of Pharmaceutical Sciences, M. D. University, Haryana

Keywords:

Pyrimidine, anti-inflammatory activity, rat paw edema

Abstract

A series of compound 6-bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one (BT₁M-T₁₀M), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (BT₁P-BT₁₀P) has been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one (T₁-T₁₀). The structures of the synthesized compounds were elucidated by I.R., ¹HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by a carrageenan-induced rat paw edema method. Among them, compounds BT₈M, BT₄P, BT₅P, and BT₇P exhibited significant anti-inflammatory activity. Compounds BT₃M, BT₉M, BT₁₀M, BT₉P, and BT₁₀P showed highly significant anti-inflammatory activity. The remaining compounds showed less anti-inflammatory activity, comparable to that of standard drug diclofenac sodium.

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Author Biographies

Anoop SINGH, Nims Institute of Pharmacy, Nims University, Rajasthan

Nims institute of Pharmacy rank Prof.

Prabhakar KUMARVERMA, Department of Pharmaceutical Sciences, M. D. University, Haryana

deptt. of pharmacy

Novel series of pyrimidine derivatives as anti-inflammatory agents

rank Proffesor

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