Novel Series of Pyrimidine Derivatives as Anti-inflammatory Agents


  • Anshu CHAYDHARY Nims Institute of Pharmacy, Nims University, Rajasthan
  • Anoop SINGH Nims Institute of Pharmacy, Nims University, Rajasthan
  • Prabhakar KUMARVERMA Department of Pharmaceutical Sciences, M. D. University, Haryana


Pyrimidine, anti-inflammatory activity, rat paw edema


A series of compound 6-bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one (BT1M-T10M), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (BT1P-BT10P) has been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one (T1-T10). The structures of the synthesized compounds were elucidated by I.R., 1HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by a carrageenan-induced rat paw edema method. Among them, compounds BT8M, BT4P, BT5P, and BT7P exhibited significant anti-inflammatory activity. Compounds BT3M, BT9M, BT10M, BT9P, and BT10P showed highly significant anti-inflammatory activity. The remaining compounds showed less anti-inflammatory activity, comparable to that of standard drug diclofenac sodium.


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Author Biographies

Anoop SINGH, Nims Institute of Pharmacy, Nims University, Rajasthan

Nims institute of Pharmacy  rank Prof.

Prabhakar KUMARVERMA, Department of Pharmaceutical Sciences, M. D. University, Haryana

deptt. of pharmacy 

Novel series of pyrimidine derivatives as anti-inflammatory agents

rank Proffesor


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How to Cite

CHAYDHARY, A., SINGH, A., & KUMARVERMA, P. (2015). Novel Series of Pyrimidine Derivatives as Anti-inflammatory Agents. Walailak Journal of Science and Technology (WJST), 13(10), 789–802. Retrieved from