Biological Activities of a Thai Luminescent Mushroom

Jiraporn BURAKORN; Trong Binh NGUEYN; Rueankeaw PRAPHRUET

Authors

Jiraporn BURAKORN Department of Science Service, Bangkok
Trong Binh NGUEYN Tay Nguyen Institute for Scientific Research, Dalat
Rueankeaw PRAPHRUET Institute of Product Quality and Standardization, Maejo University, Chiang Mai

Keywords:

Neonothopanus nimbi, luminescent mushroom, antimicrobial activity, antifungal activity, anticancer

Abstract

Wild fruit bodies of luminescent mushrooms were collected from wood stumps over a period covering August to October 2011 in the Kosumpisai forest, Mahasarakham province, in the Northeast of Thailand. A study of the morphological and genetic characteristics of the luminescent mushroom suggested that it was Neonothopanus nimbi KS. The fruiting bodies and mycelium of Neonothopanus nimbi KS were assayed for their antimicrobial activities, antifungal activity, inhibitory activity against avian influenza H5N1 neuraminidase (NA), and anticancer activity, using organic solvent extracts. The results showed that only the methanol extract of mycelia was effective against Bacillus sphaericus, with the widest inhibition zone of 11.66±2.71 mm, but this was not effective against the other 3 bacteria (Pseudomonas aeruginosa, Serratia marcescens, and Escherichia coli). On the other hand, all of the fruit body extracts were inactive against all four bacteria. The ethylacetate extract of mycelia inhibited the NCI-H187 small lung cancer cell line, KB oral cavity cancer cell line, and the MCF7 breast cancer cell line, including Magnaporthe grisea and Curvularia lunata. The methanol extract of mycelia inhibited the KB oral cavity cell cancer cell line, Magnaporthe grisea, and Curvularia lunata at 96.66, 95.32 and 95.41 %, respectively. The results imply that polar extracts of mycelia are a resource of bioactive compounds, whereas extracts of fruit bodies have less inhibitory activity against cancer, phytopathogenic-fungi and H5N1 neuraminidase.

doi:10.14456/WJST.2015.79

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Author Biography

Jiraporn BURAKORN, Department of Science Service, Bangkok

Department of Science Service,
75/7 RamaVI Road, Rathewi, Bangkok,Thailand 10400

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