Human Exposure to Glyphosate and Methods of Detection: A Review

Sunisa  CHAIKLIENG; Kodchakorn  UENGCHUEN

doi:10.48048/wjst.2020.7232

Authors

Sunisa CHAIKLIENG Department of Environmental Health, Occupational Health and Safety, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand https://orcid.org/0000-0003-4190-4930
Kodchakorn UENGCHUEN Department of Environmental Health, Occupational Health and Safety, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand

DOI:

https://doi.org/10.48048/wjst.2020.7232

Keywords:

Ambient air, Aminomethylphosphonic acid, AMPA, Exposure, Glyphosate

Abstract

Glyphosate is a broad-spectrum herbicide used extensively worldwide. The carcinogenic potential of glyphosate has been debated. This review aimed to describe human exposure, report environmental air concentrations in relation to occupational exposure, and identify the methods used to analyze glyphosate or AMPA concentrations. We searched, Google Scholar, Science Direct and PubMed for relevant papers in Thai or English, published from 2004 to 2017. Thus, 16 studies were identified. The results show that glyphosate and aminomethylphosphonic acid (AMPA) are markers of both internal and external exposure dose. Glyphosate is generally detected at concentrations comparable to or higher than AMPA. Human exposure has been assessed with measured levels of glyphosate ranging from 0.02 to 233 µg/L and a range of AMPA of 0.15 to 2.63 µg/L in human urine. The highest concentrations of glyphosate and AMPA found in blood were 171.1×10³ and 2,600 µg/L, respectively, from acute poisonings and intentional self-harm. Environmental air concentrations of glyphosate ranged from less than 0.01 to 46.80 µg/m³ in the working field areas. Four methods used to analyze glyphosate and AMPA were identified: ELISA, HPLC-fluorescence/MS, GC-MS, LC-MS. While these results indicate the level of human exposure to glyphosate, the resulting human health effects of exposure are still uncertain. Therefore, there is a need for more investigation into human health risk assessment and application of health surveillance programs, particularly among glyphosate applicators.

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Author Biography

Sunisa CHAIKLIENG, Department of Environmental Health, Occupational Health and Safety, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand

Occupational Health and Safety

Ergonomics

Toxicology

References

Office of Agricultural Economics. Quantity and Value of Agriculture’s Hazardous Substance Imported 2554 - 2560, Available at: http://oldweb.oae.go.th/economicdata/pesticides.html, accessed September 2018.

Ramathibodi Poison Center. Poison & Drug Information Bulletin, Available at: https://med.mahidol.ac.th/poisoncenter/th/bulletin/bul99/ v7n3/Herb, accessed September 2018.

J George, S Prasad, Z Mahmood and Y Shukla. Studies on glyphosate-induced carcinogenicity in mouse skin: A proteomic approach. J. Proteomics. 2010; 73, 951-64.

A Popoltap. Biomarkers for risk assessment of exposure from fungi's toxicity, Available at: http://thaimycotoxin.org/?p=316, accessed July 2018.

FJ Acquavella, HB Alexander, SJ Mandel, C Gustin, B Baker, P Chapman and M Bleeke. Glyphosate biomonitoring for farmers and their families: Results from the farm family exposure study. Environ. Health. Perspect. 2004; 112, 321-6.

US Environmental Protection Agency (EPA). Human-health Assessment Scoping Document in Support of Registration Review: Glyphosate. US. EPA Office of Prevention, Pesticides, and Toxic Substances, Office of Pesticide Programs, US. Government Printing Office, Washington, DC, 2009.

BD Curwin, MJ Hein, WT Sanderson, C Striley, D Heederik, H Kromhout, SJ Reynolds and MC Alavanja. Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in Iowa. Ann. Occup. Hyg. 2007; 51, 53-65.

R Mesnage, C Moesch, RLG Grand, G Lauthier, JSD Vendômois, S Gress and GE Sralini. Glyphosate exposure in a farmer’s family. J. Environ. Protect. 2012; 3, 1001-3.

LE Knudsen, PW Hansen, S Mizrak, HK Hansen, TA Mørck, F Nielsen, V Siersma and L Mathiesen. Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate. Rev. Environ. Health 2017; 32, 279-90.

BD Curwin, MJ Hein, WT Sanderson, C Striley, D Heederik, H Kromhout, SJ Reynolds and MC Alavanja. Pesticide dose estimates for children of Iowa farmers and non-farmers. Environ. Res. 2007; 105, 307-15.

MK McGuire, MA McGuire, WJ Price, B Shafii, JM Carrothers, KA Lackey, DA Goldstein, PK Jensen and JL Vicini. Glyphosate and aminomethylphosphonic acid are not detectable in human milk. Am. J. Clin. Nutr. 2016; 103, 1285-90.

HW Hoppe. Determination of Glyphosate Residues in Human Urine Samples from 18 European Countries. Report Glyphosate MLHB-2013-06-06, Germany, 2013, p. 1-13.

M Krüger, P Schledorn, W Schrödl, HW Hoppe, W Lutz and AA Shehata. Detection of glyphosate residues in animals and humans. J. Environ. Anal. Toxicol. 2014; 4, 1-5.

A Conrad, C Schröter-Kermani, HW Hoppe, M Rüther, S Pieper and M Kolossa-Gehring. Glyphosate in German adults - Time trend (2001 to 2015) of human exposure to a widely used herbicide. Int. J. Hyg. Environ. Health 2017; 220, 8-16.

W Polyiem, S Hongsibsong, S Chantara, T Kerdnoi, V Patarasiriwong and T Prapamontol. Determination and assessment of glyphosate exposure among farmers from northern part of Thailand. J. Pharmacol. Toxicol. 2017; 12, 97-102.

A Aris and S Leblanc. Maternal and fetal exposure to pesticides associated to genetically modiﬁed foods in Eastern Townships of Quebec. Reprod. Toxicol. 2011; 31, 528-33.

J Han, H Moon, Y Hong, S Yang, WJ Jeong, KS Lee and H Chung. Determination of glyphosate and its metabolite in emergency room in Korea. Forensic Sci. Int. 2016; 265, 41-6.

A Anadón, MR Martínez-Larrañaga, MA Martínez, VJ Castellano, M Martínez, MT Martin, MJ Nozal and JL Bernal. Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats. Toxicol. Lett. 2009; 190, 91-5.

MdM Morshed, D Omar, RB Mohamad and SBA Wahed. Determination of glyphosate through passive and active sampling methods in a treated field atmosphere. Afr. J. Agric. Res. 2011; 6, 4010-8.

A Jauhiainen, K Räsänen, R Sarantila, J Nuutinen and J Kangas. Occupational exposure of forest workers to glyphosate during brush saw spraying work. Am. Ind. Hyg. Assoc. J. 1991; 52, 61-4.

GC Smith. Glyphosate Monitoring Study Evaluation of the Exposure Rsks from Glyphosate and Associated Degradation Products from Road-side Spraying for Weed Control. 1st Ed, Government of Bermuda Ministry of the Environment, Bermuda, 2013, p. 1-31.

FC Chang, M Simcik and P Capel. Occurrence and fate of the herbicide glyphosate and its degradate aminomethyl phosphonic acid in the atmosphere. Environ. Toxicol. Chem. 2011; 30, 548-55.

C Gillezeau, MV Gerwen, RM Shaffer, I Rana, L Zhang, L Sheppard and E Taioli. The evidence of human exposure to glyphosate: A review. Environ. Health 2019; 18, 1-14.

CV Aparicio, DE Geronimo, D Marino, J Primost, P Carriquiriborde and LJ Costa. Environmental fate of glyphosate and aminomethylphosphonic acid in surface waters and soil of agricultural basins. Chemosphere 2013; 93, 1866-73.

EJ Primost, JGD Marino, CV Aparicio, LJ Costa and P Carriquiriborde. Glyphosate and AMPA, ‘pseudo-persistent’ pollutants under real-world agricultural management practices in the Mesopotamic Pampas agroecosystem. Environ. Pollut. 2017; 229, 771-9.

M Krüger, W Schrödl, J Neuhaus and AA Shehata. Field investigations of glyphosate in urine of Danish dairy cows. J. Environ. Anal. Toxicol. 2013; 3, 1-7.