Differences in Viscoelasticity of Ophthalmic Polymer Solution after Sterilization

  • Yotsanan WEERAPOL Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand
  • Pornsak SRIAMORNSAK Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand
Keywords: Viscosity, Viscoelastic, Ophthalmic drug, Polymer, Sterilization

Abstract

Polymer solution has been used for increasing viscosity of ophthalmic solution in order to prolong the retention of active drug in the eye. The ophthalmic solution must be sterilized, which may affect the rheology properties of viscosity-inducing polymers. The aim of this study was to investigate the effect of sterilization treatment on viscosity-inducing agents (i.e., poloxamer, polyvinyl alcohol; (PVA), methyl cellulose (MC), polyvinylpyrrolidone (PVP) and carbomer). The effect of membrane filtration and steam sterilization or autoclaving (121 °C, 15 Ib/inch2, 15 min) were determined. A rheometer was used to investigate the viscosity and viscoelastic properties between treated and untreated polymer solutions. The power law model, consistency index (k), and power law index (n) of polymer solution viscosity were compared. For viscoelastic properties, storage modulus and loss modulus were examined. The results demonstrated that, viscosity of carbomer and MC solution (1 and 2 %) were changed after steam sterilization. No difference in viscosity was observed for PVP, PVA and poloxamer solution, between untreated and treated samples. The storage and loss moduli of PVA solution after autoclaving were not different when comparing with the untreated polymer solution. From this study, it could be concluded that the sterilization treatment influenced the viscosity behavior and viscoelastic properties of polymer solution used as viscosity-inducing agent in ophthalmic solution. Therefore, the selection of polymer and sterilization method should be carefully considered.

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Author Biographies

Yotsanan WEERAPOL, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand

Faculty of Pharmaceutical Sciences

Pornsak SRIAMORNSAK, Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand

Department of Pharmaceutical Technology

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Published
2020-07-01
How to Cite
WEERAPOL, Y., & SRIAMORNSAK, P. (2020). Differences in Viscoelasticity of Ophthalmic Polymer Solution after Sterilization . Walailak Journal of Science and Technology (WJST), 17(7), 686-697. Retrieved from http://wjst.wu.ac.th/index.php/wjst/article/view/6341