Histological Changes in the Lung and Liver Tissues in Mice Exposed to Pyrethroid Inhalation

Authors

  • Nadeem SHEIKH Department of Zoology, University of the Punjab, Lahore
  • Saira JAVED Department of Zoology, University of the Punjab, Lahore
  • Asmatullah ASMATULLAH Department of Zoology, University of the Punjab, Lahore
  • Khawaja Raees AHMAD Department of Biological Sciences, University of Sargodha, Sargodha
  • Tahir ABBAS Department of Zoology, University of the Punjab, Lahore
  • Javaid IQBAL Department of Anatomy Shaikh Zayed Postgraduate Medical, Institute Shaikh Khalifa Bin Zayed Medical and Dental College, Lahore

Keywords:

Pyrethroid, cancer, histology, liver, lung

Abstract

Cypermethrin, a type II pyrethroid, is one of the most widely used insecticides in Pakistan. It is considered to be a safe pesticide; however, the possible health hazards of this pyrethroid have been ignored. Cypermethrin may become an air pollutant and adversely affect the health of non-target organisms, leading to acute or chronic disorders. The present work aims to investigate the effects of cypermethrin on lung and liver tissues due to inhalation exposure. The study is performed on 16 mature Swiss albino mice, including controls. The animals are divided into 4 groups (4 mice each) and exposed to 0.5 % dilution of cypermethrin in an inhalation chamber (40×35×25 cm3) for different time periods, whereas control animals are not exposed to any insecticide. The histopathological changes in lungs and liver tissues reveal that cypermethrin exposure induces time dependent changes in the liver and in the lungs. It damages the normal organization of liver tissues, causing liver injury due to necrosis, significant decrease in number of cells, and widening of sinusoids and fibrosis. Inhalation exposure of cypermethrin results in significant hyperplasia, clumping of cells and necrosis in the lungs. It also induces pulmonary edema, alveolitis, and pulmonary fibrosis by the deposition of collagen. Taking these findings together, it may be concluded that cypermethrin and other pyrethroids cause hazardous effects in non-target organisms through inhalation exposure. Serious efforts and awareness are required to monitor and reduce the insecticide induced health hazards in third world countries.

doi:10.14456/WJST.2014.67

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Author Biography

Nadeem SHEIKH, Department of Zoology, University of the Punjab, Lahore

Department of Zoology

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Published

2013-12-13

How to Cite

SHEIKH, N., JAVED, S., ASMATULLAH, A., AHMAD, K. R., ABBAS, T., & IQBAL, J. (2013). Histological Changes in the Lung and Liver Tissues in Mice Exposed to Pyrethroid Inhalation. Walailak Journal of Science and Technology (WJST), 11(10), 843–849. Retrieved from https://wjst.wu.ac.th/index.php/wjst/article/view/576