Design, Synthesis, Antimicrobial, and Antioxidant Activities of Novel-{4, 5-(substituted diphenyl)-4H-1, 2, 4-triazol-3-ylthio} Acetyl Chloride

Prabhakar Kumar VERMA; Mukesh KUMAR; Nelam MALIK; Priyanka DHIMAN; Anurag KHATAHAR

doi:10.48048/wjst.2018.2178

Authors

Prabhakar Kumar VERMA Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana
Mukesh KUMAR Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana
Nelam MALIK Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana
Priyanka DHIMAN Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana
Anurag KHATAHAR Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana

DOI:

https://doi.org/10.48048/wjst.2018.2178

Keywords:

Antibacteria, antifungus, MIC, antioxidant, structure activity relationship triazole

Abstract

A series of 20 new biologically active derivatives of 2-{4, 5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl chloride has been synthesized, with the aim to investigate antimicrobial, free radical scavenging activity. All the synthesized compounds were characterized by spectroscopic data and elemental analysis. The final compounds were tested for antibacterial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441; Gram-negative bacteria: Escherichia coli MTCC 443, and, for antifungal activity, against Candida albicans MTCC 227 and Aspergillus niger MTCC 281, taking ciprofloxacin as antibacterial and fluconazole as antifungal standard drugs. Compound 7a₆ was found to be the most effective antibacterial (MIC = 3.12 µg/ml), and compounds 7a₂and 7d₁ (MIC = 3.12 and 6.25 µg/ml) had the most effective antifungal effects on the selected strains, as compared to the standard drugs. The results of antioxidant studies revealed that compound 7b₁was found to be most active antioxidant, with 40.4±0.687 µg/ml, and compounds 7b₃, 7d₇, and 7d₄also showed promising free radical scavenging activity, as compared with the standard drug ascorbic acid.

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Author Biography

Prabhakar Kumar VERMA, Department of Pharmaceutical Sciences, Maharashi Dayanand University, Rohtak, Haryana

NAAC accrediated by Ministry of human resource and development and grade 1 by Govt. of India

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