Virulence Factors Involved in Pathogenicity of Dermatophytes

Dutsadee CHINNAPUN

Authors

Dutsadee CHINNAPUN School of Medicine, Walailak University, Nakhon Si Thammarat 80161

Keywords:

Dermatophytes, virulence factors, pathogenesis, Trichophyton, Epidermophyton, Microsporum

Abstract

Pathogenic dermatophytes are prevalent causes of a superficial cutaneous infection, which have the ability to invade keratinized structures such as skin, hairs and nails. Dermatophytes infection in the host involves 3 main steps: adherence to the host tissue, invading, and the development of a host response. In the first stage of infection, dermatophytes adhere to the surface of the keratinized tissue to reach the epidermis by using some factors that mediate adherence of dermatophytes. Various virulence factors are secreted from dermatophytes during the invading process in order to penetrate the host tissue, to obtain nutrients and survive. Antigens or metabolites from dermatophytes induce host cells to respond to pathogens by activating intracellular signaling pathways that induce the immune response against dermatophytes. Virulence factors involved in pathogenicity of dermatophytes are briefly described in this review that contribute to a better understanding of the function of virulence factors in the dermatophytes process.

doi:10.14456/WJST.2015.72

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